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Perfusion
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Reviews

Review article : Acid-base status, hypothermia and cardiac surgery

Julie A Swain

National Heart, Lung and Blood Institute, Bethesda

The optimal method of pH management during hypothermia is controversial. A review of current experimental and laboratory investigations comparing different pH schemes is presented. The biochemical and metabolic consequences of keeping pH constant (pH-stat) as compared to allowing the pH to increase with hypothermia (alpha-stat) are discussed. It is concluded that, on the basis of experimental and clinical studies, the alpha-stat pH management scheme may be preferable to that of keeping pH constant throughout a wide temperature range in humans.

Perfusion, Vol. 1, No. 4, 231-238 (1986)
DOI: 10.1177/026765918600100401
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