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Perfusion
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Prostacyclin, cardiopulmonary bypass and the alveolar capillary membrane

DK Jones

Department of Respiratory Physiology, Papworth Hosital

TW Higenbottam

Department of Respiratory Physiology, Papworth Hosital

D. Wheeldon

Department of Cardiothoracic Surgery, Papworth Hospital

J. Kneeshaw

Department of Anaesthesia Papworth Hospital

D. Bethune

Department of Anaesthesia Papworth Hospital

In a double blind controlled study of 24 patients undergoing coronary artery bypass grafting, 12 received an infusion of prostacyclin at 20 ng/kg/min during cardiopulmonary bypass in an attempt to reduce the previously reported increased alveolar capillary membrane permeability that occurs postoperatively. Prostacyclin significantly reduced platelet activation but had no effect in reducing complement activation or transpulmonary neutrophil sequestration. Alveolar epithelial permeability as assessed by measuring the clearance of inhaled 99mTc-DTPA from lung to blood did not change postoperatively in either group.

In order to fully evaluate pulmonary damage following cardiopulmonary bypass a marker for pulmonary endothelial damage may need to be used.

Perfusion, Vol. 1, No. 3, 165-173 (1986)
DOI: 10.1177/026765918600100303
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