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Reversal of protamine reaction with heparin

Joe R Utley

Divisions of Cardiac Surgery and Anaesthesia, Spartanburg General Hospital, South Carolina

Manoj A Bhatt

Divisions of Cardiac Surgery and Anaesthesia, Spartanburg General Hospital, South Carolina

D. Barton Stephens

Divisions of Cardiac Surgery and Anaesthesia, Spartanburg General Hospital, South Carolina

Henry G Kelley, JR

We recently encountered a patient who had severe cardiovascular collapse following administration of protamine. This severe protamine reaction was resistant to all forms of pharmacological therapy except for heparinization. Heparinization resulted in immediate reversal of the cardiovascular collapse.

Perfusion, Vol. 1, No. 1, 63-64 (1986)
DOI: 10.1177/026765918600100109


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A T. Pezzella, A. Ascioti, and P. Ricardi
Noncardiogenic pulmonary oedema following cardiopulmonary bypass: report of two cases and review of the literature
Perfusion, January 1, 1988; 3(1): 21 - 28.
[Abstract] [PDF]